IMMT (inner membrane mitochondrial protein), also known as Mic60 or mitofilin, is a critical structural component of the MICOS complex, a multiprotein assembly embedded in the mitochondrial inner membrane. IMMT maintains crista junctions, inner membrane architecture, and mitochondrial-outer membrane contact sites, thereby preserving mitochondrial cristae morphology and MICOS complex stability 1. Mechanistically, IMMT regulates mitochondrial dynamics and oxidative stress responses; its K63-linked ubiquitination at K211 initiates mitophagy for mitochondrial quality control 23. Loss of IMMT expression associates with severe mitochondrial dysfunction and reduced antioxidant capacity 4. Clinically, elevated IMMT expression correlates with poor outcomes in breast cancer by promoting cell cycle progression and creating an immunosuppressive tumor microenvironment 1. Conversely, low IMMT expression in pancreatic and renal cancers predicts aggressive disease and poor prognosis, coupled with mitochondrial inhibition and angiogenic activation 45. Beyond cancer, IMMT has emerged as a candidate gene in late-onset Parkinson's disease pathogenesis 6, and its perturbation regulates cellular senescence markers 7. These findings establish IMMT as a dual biomarker with context-dependent prognostic significance and therapeutic potential across malignancies and neurodegenerative diseases.