Based on limited published evidence, IMPACT is a translational regulator that maintains protein synthesis during stress conditions including amino acid starvation, UV irradiation, and glucose deprivation. It functions as a negative regulator of EIF2AK4/GCN2 kinase, preventing GCN2-mediated eIF2-alpha phosphorylation and subsequent translation shutdown. IMPACT may regulate neuronal translation under stress and promote neurite outgrowth through GCN2 inhibition, supporting neuronal cell differentiation.