INTS2 is a component of the integrator complex, a multiprotein complex that terminates RNA polymerase II transcription in promoter-proximal regions 12. The complex provides quality control during transcription elongation by catalyzing CTD dephosphorylation, degrading nascent RNA transcripts, and promoting Pol II release 12. INTS2 also participates in terminating non-coding Pol II transcripts including snRNAs, eRNAs, and lncRNAs 3, and mediates cytoplasmic dynein recruitment to the nuclear envelope 4. Based on limited published evidence, INTS2 has been identified as a candidate gene in autosomal recessive Parkinson's disease 5.