INTS14 is a component of the integrator complex, a multiprotein machine that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes 1. Specifically, INTS14 forms part of the integrator tail module within a scorpion-tail-shaped INTS10-INTS13-INTS14-INTS15 structure that facilitates Pol II removal from DNA 1. The INTS10-INTS13-INTS14 module functions as a nucleic acid-binding unit with preference for RNA hairpins, bringing the catalytic cleavage module into proximity with target transcripts 2. The integrator complex terminates transcription through three mechanisms: dephosphorylating Pol II's C-terminal domain, degrading nascent RNA via endonuclease activity, and promoting Pol II release 1. Beyond protein-coding genes, INTS14 participates in terminating synthesis of non-coding Pol II transcripts including snRNAs, eRNAs, and lncRNAs 2. Clinically, INTS14 overexpression correlates with elevated MYC mRNA in prostate and liver cancers, suggesting roles in oncogenic transcription regulation 3. INTS14 knockdown decreases MYC expression and induces cell cycle arrest, indicating therapeutic relevance in cancer treatment 3.