INTS6 (integrator complex subunit 6) is a core component of the Integrator complex, a multiprotein machine that terminates RNA polymerase II (Pol II) transcription at promoter-proximal pause sites 12. INTS6 functions as a molecular adapter that recruits protein phosphatase 2A (PP2A) to the Integrator core complex, enabling dephosphorylation of Pol II and associated factors like DSIF and SPT5 12. The Integrator complex also degrades nascent RNA transcripts and removes Pol II from DNA, serving as a quality checkpoint to eliminate poorly configured transcription units, including non-coding RNAs such as snRNAs, eRNAs, and lncRNAs 34. Additionally, INTS6 associates with the SOSS1 complex at DNA double-strand breaks, facilitating PP2A recruitment and DNA:RNA hybrid resolution 5. Beyond transcriptional control, INTS6 exhibits tumor suppressor activity; loss of INTS6 confers resistance to CDK9 inhibition in cancer cells and promotes hepatocellular steatosis via β-catenin-PPARγ signaling 26. Recently, INTS6 mutations were identified as causing neurodevelopmental disorders characterized by language delays, autism, and intellectual disability, with cellular studies revealing disrupted neurogenesis and impaired synaptic gene expression 7.