INTS13 is a core component of the Integrator complex that regulates RNA polymerase II transcription termination and transcriptional quality control 1. As part of the INTS10-INTS13-INTS14-INTS15 tail module, INTS13 adopts a scorpion-tail-shaped structure that facilitates transcription termination by opening the DSIF DNA clamp and promoting polymerase release from DNA 1. The protein functions as a platform for recruiting transcription factors at promoters, with specific interactions identified with ZNF655 and the EGR1/2-NAB2 axis 23. INTS13 binds nucleic acids through the INTS10-INTS13-INTS14 module, showing preference for RNA hairpins, and directly connects to the Integrator cleavage module via its conserved C-terminal motif 4. Beyond transcriptional regulation, INTS13 plays essential roles in ciliogenesis and development, with mutations causing autosomal recessive ciliopathies characterized by oral-facial-digital syndrome features 5. The protein is significantly overexpressed in multiple cancer types, including cervical cancer, where it promotes malignant phenotypes through the ZNF384-INTS13-hnRNPC signaling axis 6. INTS13 also functions in cell cycle regulation, mediating dynein recruitment to the nuclear envelope and contributing to proper spindle formation during mitosis.