INTS6L — integrator complex subunit 6 like

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

14PubMed Papers

#15,999 · top 82% of 19K genes

20Diseases

top 81%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

centrosomeintegrator complexsnRNA 3'-end processingprotein-macromolecule adaptor activityMobius syndromeMoebius syndromeHemolytic anemia due to red cell pyruvate kinase deficiencymicrocytic anemia with liver iron overload

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

integrator complex subunit 6 like

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

Mobius syndromeOpen Targets

0.11Weak

Moebius syndromeOpen Targets

0.11Weak

Hemolytic anemia due to red cell pyruvate kinase deficiencyOpen Targets

0.05Suggestive

microcytic anemia with liver iron overloadOpen Targets

0.04Suggestive

congenital dyserythropoietic anemia type 4Open Targets

0.04Suggestive

Congenital dyserythropoietic anemia type IVOpen Targets

0.04Suggestive

IRIDA syndromeOpen Targets

0.04Suggestive

hemolytic anemia due to erythrocyte adenosine deaminase overproductionOpen Targets

0.04Suggestive

hypertriglyceridemia 2Open Targets

0.04Suggestive

Rh deficiency syndromeOpen Targets

0.04Suggestive

Familial hemophagocytic lymphohistiocytosisOpen Targets

0.03Suggestive

Combined hyperlipidemiaOpen Targets

0.03Suggestive

fish eye diseaseOpen Targets

0.03Suggestive

Fish-eye diseaseOpen Targets

0.03Suggestive

Adult-onset autosomal recessive sideroblastic anemiaOpen Targets

0.03Suggestive

sideroblastic anemia 3Open Targets

0.03Suggestive

overhydrated hereditary stomatocytosisOpen Targets

0.03Suggestive

hypoparathyroidism, familial isolated, 2Open Targets

0.03Suggestive

hypoalphalipoproteinemia, primary, 1Open Targets

0.03Suggestive

homozygous familial hypercholesterolemiaOpen Targets

0.03Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Bone Marrow

100%

Ovary

33%

Lung

15%

Heart

Brain

Liver

Gene Interaction Network6 neighbors

Click a node to explore

StructureAlphaFold

Preparing viewer…

AlphaFoldAI-predicted · UniProt Q5JSJ4

View on AlphaFold

ConstraintgnomAD v4.1

LOEUFⓘ

0.41Moderately Constrained

pLIⓘ

1.00Intolerant

Observed/Expected LoF0.28 [0.19–0.41]

Rankings2 dim

Where INTS6L stands among ~20K protein-coding genes

#15,893of 20,598
Most Researched14
#2,136of 17,882
Most Constrained (LOEUF)0.41 · top quartile