IPMK (inositol polyphosphate multikinase) is a multifunctional kinase with broad substrate specificity that catalyzes phosphorylation of inositol 1,4,5-trisphosphate to inositol 1,3,4,5-tetrakisphosphate and subsequently to inositol 1,3,4,5,6-pentakisphosphate, while also phosphorylating the signaling phospholipid PIP2 12. Beyond its canonical inositol phosphate biosynthetic role, IPMK functions as a multifactorial regulator of cellular signaling with distinct catalytic and non-catalytic mechanisms 3. Structurally, IPMK contains disordered domains that modulate ATP binding and kinase activity through an N-terminal "ATP-clamp" mechanism 2. IPMK regulates transcription and histone acetylation by controlling HDAC3 activity through IPMK-dependent inositol phosphates, particularly IP4 4. In immune signaling, IPMK interacts with TRAF6 to regulate TLR4-mediated inflammation, with LPS-triggered miR-181c-mediated downregulation modulating inflammatory responses 5. IPMK is essential for embryonic development and influences human longevity through gender-specific genetic variants 6. Clinically, IPMK dysregulation is implicated in asthma pathogenesis via HIF2α-mediated promotion of pathogenic Th2 cell differentiation through PIP3 synthesis regulation 7, positioning IPMK as a potential therapeutic target in inflammation, cancer, and neurodegeneration 3.