IPO7 (importin 7) is a member of the importin-β family that functions as a nuclear import receptor, facilitating the transport of proteins and viral components from the cytoplasm to the nucleus 12. The protein mediates nuclear translocation through direct binding to cargo proteins, including flavivirus core proteins and HPV L2 protein, which is essential for viral replication and infection 12. IPO7 also transports cellular transcription factors like HOXA10 and YAP to the nucleus, where they regulate gene expression programs involved in cancer progression 34. In pathological contexts, IPO7 is frequently overexpressed in various cancers including pancreatic, oral squamous cell carcinoma, and colorectal cancer, where it promotes tumor growth, metastasis, and therapeutic resistance 536. The protein activates oncogenic signaling pathways including ERBB2, Hippo-YAP, and PERK/ATF4, while also enhancing protective autophagy in cancer cells 543. Additionally, IPO7 participates in inflammatory responses by mediating nuclear translocation of phosphorylated p38 MAPK, contributing to conditions like pulpitis 7. These diverse functions make IPO7 a potential therapeutic target for both cancer and viral infections.