KPNB1 (karyopherin subunit beta 1) functions as a nuclear transport receptor that mediates the import of proteins from the cytoplasm to the nucleus 1. The protein facilitates nuclear translocation of various cargo molecules, including transcription factors, by interacting with importin-α proteins and recognizing nuclear localization signals 2. KPNB1 demonstrates broad cellular functions beyond basic nuclear transport. It promotes endothelial cell-derived extracellular vesicle-mediated neutrophil trafficking during sepsis-associated lung injury 3 and facilitates autophagy regulation through nuclear export mechanisms 4. In ischemia-induced angiogenesis, KPNB1 enables nuclear translocation of transcription factors like ZNF148, affecting downstream gene expression 5. The protein shows significant disease relevance in cancer, where it is frequently upregulated to promote tumor progression 1. In glioblastoma, KPNB1 mediates nuclear import of transcription factor YBX1, leading to increased NLGN3 expression and enhanced tumor growth 6. Its stability is regulated by the deubiquitinase USP7 6. KPNB1 also contributes to chemotherapy resistance in colorectal cancer by facilitating nuclear translocation of phosphorylated RFNG, which subsequently inhibits p53-mediated apoptosis and ferroptosis 2. These findings highlight KPNB1 as a potential therapeutic target in multiple disease contexts.