NUP160 encodes nucleoporin 160, a structural component of the nuclear pore complex (NPC) that facilitates nucleocytoplasmic transport and mRNA export 1. The protein functions as part of the nuclear pore outer ring and is involved in poly(A)+ RNA transport across the nuclear envelope 1. In kidney physiology, NUP160 plays a critical role in podocyte function, where its knockdown impairs cell proliferation, induces apoptosis and autophagy, and alters the expression and localization of key podocyte-associated molecules including nephrin, podocin, and CD2AP 2. NUP160 regulates autophagy through the JAK2/STAT3 signaling pathway, with decreased NUP160 levels associated with enhanced autophagy suppression 3. Pathogenic variants in NUP160 cause autosomal recessive steroid-resistant nephrotic syndrome (SRNS), typically presenting with focal segmental glomerulosclerosis and onset around age 7 years 14. Functional validation in Drosophila nephrocytes demonstrates that NUP160 mutations lead to cellular abnormalities including reduced cell size, altered nuclear architecture, and disrupted nuclear pore complex organization 4. The protein has also been implicated in cancer progression, particularly in lung adenocarcinoma where it contributes to autophagy suppression and metastasis 5.