ITGAX (integrin subunit alpha X, also known as CD11c) encodes the alpha subunit of the integrin αXβ2 receptor, primarily expressed on myeloid and B cell populations. ITGAX functions as an adhesion molecule mediating cell-cell interactions critical for inflammatory responses and immune cell trafficking. The receptor recognizes fibrinogen and mediates leukocyte adhesion during immune activation 1. Mechanistically, ITGAX is regulated by transcriptional factors controlling immune cell differentiation. ZEB2 transcription factor directly targets ITGAX as part of age-associated B cell (ABC) specification 2. ITGAX expression defines functionally distinct immune cell populations: ITGAX+TBX21+ autoimmune-associated B cells expanded in rheumatoid arthritis synovial tissue 3, and Tbet+CD11c+ B cells that develop through T follicular helper cell help independently of germinal centers 4. Clinically, ITGAX elevation associates with multiple pathologies. In rheumatoid arthritis, ITGAX+ B cells represent key inflammatory mediators in joint disease 3. ITGAX expression marks pro-inflammatory decidual macrophages involved in preeclampsia pathogenesis 5. ITGAX serves as a shared dendritic cell and immune marker in atopic dermatitis and psoriasis lesional skin 6. In atherosclerosis, ITGAX ranks among six hub genes with significantly elevated expression in atheroma plaques 7, suggesting roles in both adaptive immunity and vascular inflammation.