JAKMIP1 (Janus kinase and microtubule interacting protein 1) is a multifunctional protein that serves as a critical regulator of neuronal translation and synaptic function. The protein functions as a component of polyribosomes and ribonucleoprotein translational regulatory complexes, working alongside fragile X mental retardation protein, DEAD box helicase 5, and poly(A) binding protein cytoplasmic 1 to control mRNA translation during synaptogenesis 1. JAKMIP1 associates with microtubules and colocalizes with the microtubule cytoskeleton, potentially facilitating microtubule-dependent transport processes 2. The protein is predominantly expressed in neural and lymphoid tissues, with particularly high expression in brain and retina 3. In the immune system, JAKMIP1 is absent in naive T cells but highly expressed in antigen-experienced effector T cells, where it functions as an inhibitory regulator of cytotoxic T lymphocyte activity 2. Loss of JAKMIP1 function dysregulates neuronal translation, affects glutamatergic NMDAR signaling, and results in autism-like behaviors including social deficits and stereotyped activities in mouse models 1. The protein has also been implicated in cancer biology, where overexpression associates with Wnt/β-catenin pathway activation and enhanced cancer cell proliferation 4. These findings establish JAKMIP1 as an important regulator of both neurodevelopmental processes and immune function.