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GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
KCTD4
potassium channel tetramerization domain containing 4
Chromosome 13 Β· 13q14.12-q14.13
NCBI Gene: 386618Ensembl: ENSG00000180332.7HGNC: HGNC:23227UniProt: Q8WVF5
12PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingidentical protein bindingprotein homooligomerizationcanceresophageal squamous cell carcinomaalcohol drinkingamputation
✦AI Summary

Based on limited published evidence, KCTD4 is a protein containing a potassium channel tetramerization domain with protein binding capability. The gene was identified as a variant in cell-free DNA associated with cancer screening in dense breast tissue 1, though its specific molecular function remains poorly characterized. No functional studies directly investigating KCTD4's role in potassium channel biology or other cellular processes have been published.

Sources cited
1
KCTD4 was identified as a gene harboring SNP variants in cell-free DNA from breast cancer screening samples
PMID: 35589867
⚠Limited data available β€” This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
cancerOpen Targets
0.07Suggestive
esophageal squamous cell carcinomaOpen Targets
0.07Suggestive
alcohol drinkingOpen Targets
0.07Suggestive
amputationOpen Targets
0.06Suggestive
balanoposthitisOpen Targets
0.06Suggestive
acute tonsillitisOpen Targets
0.04Suggestive
frozen shoulderOpen Targets
0.03Suggestive
trauma complicationOpen Targets
0.03Suggestive
glioblastoma multiformeOpen Targets
0.03Suggestive
neoplasmOpen Targets
0.02Suggestive
cystic fibrosisOpen Targets
0.02Suggestive
colorectal adenocarcinomaOpen Targets
0.02Suggestive
medulloblastomaOpen Targets
0.02Suggestive
astrocytomaOpen Targets
0.01Suggestive
oligodendrogliomaOpen Targets
0.01Suggestive
psoriasisOpen Targets
0.01Suggestive
esophageal cancerOpen Targets
0.01Suggestive
prostate cancerOpen Targets
0.01Suggestive
ependymomaOpen Targets
0.01Suggestive
myxosarcomaOpen Targets
0.01Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
KCTD3Shared pathway100%IKZF4Shared pathway100%KCTD14Shared pathway100%KCTD15Shared pathway100%SAMD1Shared pathway100%KCTD18Shared pathway100%
Tissue Expression6 tissues
Brain
100%
Bone Marrow
23%
Heart
7%
Ovary
1%
Liver
0%
Lung
0%
Gene Interaction Network
Click a node to explore
KCTD4KCTD3IKZF4KCTD14KCTD15SAMD1KCTD18
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted Β· UniProt Q8WVF5
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.01LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.63 [0.40–1.01]
RankingsWhere KCTD4 stands among ~20K protein-coding genes
  • #16,481of 20,598
    Most Researched12
  • #9,906of 17,882
    Most Constrained (LOEUF)1.01
Genes detectedKCTD4
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
Evaluation of cfDNA as an early detection assay for dense tissue breast cancer.
PMID: 35589867
Sci Rep Β· 2022
1.00