KHDRBS1 (also known as Sam68) is an RNA-binding adaptor protein that regulates multiple cellular processes including metabolism, cell cycle control, and cancer progression. The protein functions as a post-transcriptional regulator through RNA stabilization mechanisms, as demonstrated by its binding to SNORD51 to enhance RNA stability and its interaction with SCD1 mRNA 3'UTR to increase mRNA stability 12. In metabolic regulation, KHDRBS1 promotes hepatic gluconeogenesis by stabilizing CRTC2 protein through reduced ubiquitination, with hepatic expression upregulated in diabetic patients 3. The protein plays complex roles in cancer, acting as both oncogene and tumor suppressor depending on context. In hepatocellular carcinoma, KHDRBS1 promotes tumor progression and correlates with poor prognosis 4, while in glioblastoma it regulates the pentose phosphate pathway through the SNORD51/ZBED6 axis 2. However, KHDRBS1-deficient tumors show enhanced sensitivity to certain treatments, suggesting context-dependent tumor-suppressive functions 5. The protein also contributes to leukemogenesis as part of MLL oncogenic complexes 6 and has been associated with primary ovarian insufficiency 7. These diverse functions highlight KHDRBS1's importance in cellular homeostasis and disease pathogenesis.