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10 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
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KIF14
kinesin family member 14
Chromosome 1 Β· 1q32.1
NCBI Gene: 9928Ensembl: ENSG00000118193.13HGNC: HGNC:19181UniProt: A0A384P5W4
140PubMed Papers
22Diseases
0Drugs
43Pathogenic Variants
FUNCTIONAL ROLE
Hub Gene
CLINICAL
OMIM Disease Gene
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
regulation of Rap protein signal transductionnegative regulation of integrin activationsubstrate adhesion-dependent cell spreadingestablishment of protein localizationlethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndromemicrocephaly 20, primary, autosomal recessiveautosomal recessive primary microcephalyneurodegenerative disease
✦AI Summary

KIF14 is a microtubule motor protein that plays critical roles in cell division, cytokinesis, and tumor progression. The protein functions as a key regulator of cytokinesis by targeting to the central spindle and midbody through interactions with PRC1 and CIT 1. KIF14 is significantly overexpressed across multiple cancer types, including cholangiocarcinoma, gastric cancer, glioblastoma, triple-negative breast cancer, retinoblastoma, lung adenocarcinoma, medulloblastoma, and colorectal cancer 23456789. High KIF14 expression consistently correlates with poor prognosis, increased metastasis, and chemotherapy resistance 238. Mechanistically, KIF14 promotes tumor progression through multiple pathways including AKT signaling 34, NF-ΞΊB activation via G3BP1/YBX1 complex binding 2, and regulation of immune infiltration 75. KIF14 silencing inhibits cell proliferation, migration, invasion, and induces apoptosis, while promoting G2/M cell cycle arrest 48. The protein serves as an independent prognostic biomarker and potential therapeutic target across multiple malignancies 98.

Sources cited
1
KIF14 promotes proliferation, metastasis, and chemoresistance through NF-ΞΊB pathway activation via G3BP1/YBX1 complex in cholangiocarcinoma
PMID: 36922675
2
KIF14 is overexpressed in gastric cancer and promotes progression through AKT signaling pathway
PMID: 30404039
3
KIF14 inhibition suppresses glioblastoma growth and induces apoptosis through AKT inactivation
PMID: 26536004
4
KIF14 promotes TNBC progression and serves as prognostic biomarker with involvement in multiple signaling pathways
PMID: 41410179
5
KIF14 is overexpressed in retinoblastoma tumors and correlates with disease phenotype
PMID: 19190782
6
KIF14 overexpression in lung adenocarcinoma is associated with tumor immune infiltration and poor prognosis
PMID: 36227151
7
KIF14 is overexpressed in medulloblastoma and its downregulation suppresses proliferation and induces apoptosis
PMID: 28504687
8
KIF14 expression has prognostic impact in colorectal cancer and correlates with genomic instability
PMID: 34575892
Disease Associationsβ“˜22
lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndromeOpen Targets
0.73Strong
microcephaly 20, primary, autosomal recessiveOpen Targets
0.72Strong
autosomal recessive primary microcephalyOpen Targets
0.66Moderate
neurodegenerative diseaseOpen Targets
0.55Moderate
Meckel syndromeOpen Targets
0.51Moderate
Joubert syndrome and related disordersOpen Targets
0.40Moderate
genetic disorderOpen Targets
0.19Weak
hepatocellular carcinomaOpen Targets
0.11Weak
neoplasmOpen Targets
0.11Weak
lysosomal storage diseaseOpen Targets
0.11Weak
lung adenocarcinomaOpen Targets
0.10Weak
colorectal carcinomaOpen Targets
0.10Weak
nonpapillary renal cell carcinomaOpen Targets
0.09Suggestive
posterior cortical atrophyOpen Targets
0.08Suggestive
oral squamous cell carcinomaOpen Targets
0.08Suggestive
cervical cancerOpen Targets
0.07Suggestive
breast cancerOpen Targets
0.07Suggestive
cancerOpen Targets
0.07Suggestive
coronary artery diseaseOpen Targets
0.07Suggestive
nasopharyngeal carcinomaOpen Targets
0.06Suggestive
Meckel syndrome 12UniProt
Microcephaly 20, primary, autosomal recessiveUniProt
Pathogenic Variants43
NM_014875.3(KIF14):c.2609_2610del (p.Tyr870fs)Pathogenic
not provided
β˜…β˜…β˜†β˜†2026β†’ Residue 870
NM_014875.3(KIF14):c.103C>T (p.Arg35Ter)Pathogenic
not provided|Microcephaly 20, primary, autosomal recessive
β˜…β˜…β˜†β˜†2024β†’ Residue 35
NM_014875.3(KIF14):c.3661+1G>TLikely pathogenic
not provided|Joubert syndrome and related disorders|KIF14-related disorder|Clear cell carcinoma of kidney
β˜…β˜…β˜†β˜†2024
NM_014875.3(KIF14):c.4094del (p.Ser1364_Ser1365insTer)Likely pathogenic
Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome;Microcephaly 20, primary, autosomal recessive
β˜…β˜…β˜†β˜†2024β†’ Residue 1364
NM_014875.3(KIF14):c.246_247insG (p.Asn83fs)Pathogenic
not provided
β˜…β˜†β˜†β˜†2026β†’ Residue 83
NM_014875.3(KIF14):c.374_375dup (p.Lys126fs)Pathogenic
not provided
β˜…β˜†β˜†β˜†2026β†’ Residue 126
NM_014875.3(KIF14):c.4059_4060insACTTACAA (p.Leu1354fs)Pathogenic
not provided
β˜…β˜†β˜†β˜†2026β†’ Residue 1354
NM_014875.3(KIF14):c.1936C>T (p.Gln646Ter)Pathogenic
not provided
β˜…β˜†β˜†β˜†2026β†’ Residue 646
NM_014875.3(KIF14):c.2813+1G>CLikely pathogenic
not provided
β˜…β˜†β˜†β˜†2025
NM_014875.3(KIF14):c.3886+1_3886+2delLikely pathogenic
not provided
β˜…β˜†β˜†β˜†2025
NM_014875.3(KIF14):c.834_835insGGGGGGATTGAGCCAAGATGGCCGAATAGGAACAGCTCCGGTCTACAGCTCCCAGCGTGAGCAACGCAGAAGACGGTGANNNNNNNNNNAAAAAAAAAAAAAAAAAAAAAGAAAAAAGAACACCT (p.Thr279delinsGlyGlyIleGluProArgTrpProAsnArgAsnSerSerGlyLeuGlnLeuProAlaTer)Pathogenic
not provided
β˜…β˜†β˜†β˜†2025β†’ Residue 279
NM_014875.3(KIF14):c.1712_1746+27delLikely pathogenic
Joubert syndrome and related disorders
β˜…β˜†β˜†β˜†2025
NM_014875.3(KIF14):c.3662G>T (p.Gly1221Val)Likely pathogenic
Microcephaly 20, primary, autosomal recessive|Joubert syndrome and related disorders
β˜…β˜†β˜†β˜†2025β†’ Residue 1221
NM_014875.3(KIF14):c.3910C>T (p.Gln1304Ter)Pathogenic
Microcephaly 20, primary, autosomal recessive
β˜…β˜†β˜†β˜†2025β†’ Residue 1304
NM_014875.3(KIF14):c.4475del (p.Asp1492fs)Likely pathogenic
Microcephaly 20, primary, autosomal recessive
β˜…β˜†β˜†β˜†2024β†’ Residue 1492
NM_014875.3(KIF14):c.1989_1993del (p.Glu664fs)Likely pathogenic
Microcephaly 20, primary, autosomal recessive;Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome
β˜…β˜†β˜†β˜†2024β†’ Residue 664
NM_014875.3(KIF14):c.1123G>T (p.Glu375Ter)Likely pathogenic
Microcephaly 20, primary, autosomal recessive;Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome
β˜…β˜†β˜†β˜†2024β†’ Residue 375
NM_014875.3(KIF14):c.955del (p.Ser319fs)Likely pathogenic
Microcephaly 20, primary, autosomal recessive;Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome
β˜…β˜†β˜†β˜†2024β†’ Residue 319
NM_014875.3(KIF14):c.3619C>T (p.Gln1207Ter)Likely pathogenic
Microcephaly 20, primary, autosomal recessive;Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome
β˜…β˜†β˜†β˜†2024β†’ Residue 1207
NM_014875.3(KIF14):c.1021_1022del (p.Val341fs)Likely pathogenic
Microcephaly 20, primary, autosomal recessive;Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome
β˜…β˜†β˜†β˜†2024β†’ Residue 341
View on ClinVar β†—
Related Genes
NCAPGProtein interaction100%SMC4Protein interaction100%CEP55Protein interaction100%TUBA1BProtein interaction100%HJURPProtein interaction95%KIF4AProtein interaction95%
Tissue Expression6 tissues
Bone Marrow
100%
Brain
18%
Lung
2%
Liver
2%
Ovary
1%
Heart
0%
Gene Interaction Network
Click a node to explore
KIF14NCAPGSMC4CEP55TUBA1BHJURPKIF4A
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted Β· UniProt Q15058
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
0.65LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.51 [0.41–0.65]
RankingsWhere KIF14 stands among ~20K protein-coding genes
  • #3,279of 20,598
    Most Researched140 Β· top quartile
  • #1,462of 5,498
    Most Pathogenic Variants43
  • #4,712of 17,882
    Most Constrained (LOEUF)0.65
Genes detectedKIF14
Sources retrieved10 papers
Response timeβ€”
πŸ“„ Sources
10β–Ό
1
KIF14 promotes proliferation, lymphatic metastasis and chemoresistance through G3BP1/YBX1 mediated NF-ΞΊB pathway in cholangiocarcinoma.
PMID: 36922675
Oncogene Β· 2023
1.00
2
KIF14 promotes tumor progression and metastasis and is an independent predictor of poor prognosis in human gastric cancer.
PMID: 30404039
Biochim Biophys Acta Mol Basis Dis Β· 2019
0.90
3
Inhibition of KIF14 Suppresses Tumor Cell Growth and Promotes Apoptosis in Human Glioblastoma.
PMID: 26536004
Cell Physiol Biochem Β· 2015
0.80
4
Validation of the important role and prognostic value of KIF14 in triple-negative breast cancer.
PMID: 41410179
Cancer Biol Ther Β· 2025
0.70
5
KIF14 and E2F3 mRNA expression in human retinoblastoma and its phenotype association.
PMID: 19190782
Mol Vis Β· 2009
0.60