KIF15 is a plus-end directed microtubule motor protein that plays essential roles in mitotic spindle assembly and chromosome 3 during cell division 1. As a member of the kinesin-12 family, KIF15 exhibits chr3 properties with DNA-binding capacity and contributes to chromosome 3 through polar ejection forces 1. The protein's localization and motility are regulated by the C-terminal domain of TPX2, which suppresses motor walking in vitro while enabling force generation required for bipolar spindle formation 2. Beyond its mitotic functions, KIF15 has emerged as a significant oncogenic factor across multiple cancer types. In prostate cancer, KIF15 directly binds AR/AR-V7 proteins and prevents their degradation, contributing to enzalutamide resistance 3. In glioblastoma, KIF15 promotes cell proliferation and metastasis under transcriptional control by REST and P300 4. Similarly, KIF15 upregulation drives tumorigenicity in melanoma through regulation of BIRC5, CDK4, and WNT5A pathways 5. Notably, KIF15 deficiency affects neuronal synaptic development, leading to mood disorders in mice through interactions with PSD95 and altered dendritic spine morphology 6. KIF15 is also associated with idiopathic pulmonary fibrosis susceptibility 7, highlighting its diverse pathological roles beyond cancer.