KPNA2 (karyopherin subunit alpha 2) functions as a nuclear import adapter protein that facilitates the transport of cargo proteins containing nuclear localization sequences (NLS) into the nucleus through interaction with KPNB1 1. The protein plays critical roles in multiple cellular processes including angiogenesis, where KPNA2 promotes STAT3 phosphorylation under hypoxic conditions, leading to upregulation of VEGF and ANGPT2 2. In cancer progression, KPNA2 is overexpressed in various malignancies and associated with poor prognosis 1. The protein facilitates nuclear translocation of key transcription factors such as CREB3L1 in anaplastic thyroid carcinoma, promoting tumor growth and metastasis through extracellular matrix signaling 3. KPNA2 also maintains cancer stem cell characteristics through ISGylation-mediated protein stabilization 4. In neurological contexts, KPNA2 regulates ERK1/2 nuclear translocation, with enhanced nuclear ERK signaling providing neuroprotection in models of Huntington's, Alzheimer's, and Parkinson's diseases 5. Additionally, KPNA2 mediates p65 nuclear translocation in the NF-κB pathway during viral infections, contributing to innate immune responses 6. The protein's involvement in alternative splicing regulation and exosome-mediated intercellular communication further demonstrates its multifaceted roles in cellular homeostasis and disease progression 78.