KRT10 (keratin 10) is a structural intermediate filament protein predominantly expressed in suprabasal differentiated keratinocytes of the normal skin epidermis 1. It functions as a critical component of the cornified envelope and plays essential roles in keratinocyte differentiation and epidermal morphogenesis through protein heterodimerization and intermediate filament organization [provided by GO annotations and abstracts]. Mechanistically, KRT10 expression is dynamically regulated during epidermal homeostasis and wound repair. During normal skin wound healing, KRT10 is downregulated as part of a coordinated shift where keratinocytes suppress KRT10-KRT1 expression and upregulate injury-response keratins (KRT16/KRT17-KRT6) 1. In atopic dermatitis, IL19-mediated downregulation of KRT10 in keratinocytes contributes to barrier disruption and inflammatory activation 2. KRT10 downregulation is associated with impaired epidermal maturation during wound healing 3. Pathogenic KRT10 variants cause several ichthyotic disorders including epidermolytic hyperkeratosis and ichthyosis with confetti. In a large 1000-kindred ichthyosis cohort, KRT10 mutations were significantly associated with skin pain, odor, and infections (odds ratios 6.8, 5.7, and 3.1 respectively) compared to other ichthyosis genotypes 4. Additionally, KRT10 participates in inflammatory disease networks relevant to inflammatory bowel disease and may serve as a therapeutic target in inflammatory conditions 5.