KRT24 (keratin 24) is a cytoskeletal protein that functions as a structural component of intermediate filaments, providing mechanical stability to epithelial cells 1. The protein is highly expressed in corneal epithelium, with significantly lower expression levels in other stratified epithelia including the epidermis 2. KRT24 serves as a differentiation marker, particularly in corneal epithelial cells and amnion-like tissues during mid-gestation development 3. Mechanistically, KRT24 facilitates tumor cell migration, invasion, and metastasis in various cancers 1. The gene shows dramatic upregulation (49.446-fold) in pterygium tissues and responds to UV-B radiation exposure in corneal epithelial cells, suggesting involvement in UV stress responses 4. Disease relevance includes association with aggressive bladder cancer variants characterized by a CA125+ cell state 5, poor prognosis in breast cancer with correlation to high histological grade and treatment resistance 1, and inflammatory bowel disease susceptibility 6. Clinically, KRT24 expression predicts poor survival outcomes, higher risk of distant metastases, and chemotherapy resistance in cancer patients 1, potentially serving as both a prognostic biomarker and therapeutic target for aggressive malignancies.