KRT37 is a type I keratin intermediate filament protein involved in epithelial structure and hair development. As a structural constituent of the epidermis, KRT37 functions in cytoskeleton organization, epithelial cell differentiation, and keratin filament assembly 1. The protein is expressed in hair follicles, with specific localization patterns in hair fiber compartments, particularly in the cortex region where it contributes to hair structural integrity 2. In disease contexts, KRT37 expression is significantly altered in oral dysplasia. Dysplastic oral leukoplakia shows downregulation of KRT37 compared to non-dysplastic leukoplakia, with reduced KRT37 levels associated with extracellular matrix pathway dysfunction—a hallmark feature of dysplastic lesions 3. Additionally, rare KRT37 variants have been identified in familial celiac disease, where a nonsense mutation segregated with disease in an affected family, suggesting potential involvement in the genetic architecture of this immune-mediated disorder, though causality remains to be established 4. Clinically, recombinant KRT37 demonstrates therapeutic potential for wound healing, with KRT37-derived nanoparticles significantly enhancing dermal wound closure through improved epithelialization, vascularization, and collagen deposition without systemic toxicity 1.