2 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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15PubMed Papers
0Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingstructural constituent of skin epidermismorphogenesis of an epitheliumepithelial cell differentiation
Based on limited published evidence, KRT39 is a type II keratin protein involved in intermediate filament organization and epithelial cell differentiation. UniProt annotations indicate a potential role in late hair differentiation. KRT39 localizes to the cytoskeleton and cytoplasm and functions as a structural constituent of skin epidermis. Genome-wide analysis in yak identified KRT39 within a module associated with hair follicle development and keratinocyte proliferation 1. KRT39 gene amplification has been detected in HER2-positive gastric cancer samples 2, though the functional significance in cancer remains unclear.
1
KRT39 identified in thistle2 module related to hair follicle development, cell cycle regulation, and keratinocyte proliferation in genome-wide keratin analysis
PMID: 350857102
KRT39 gene amplification detected in HER2-positive gastric cancer samples
PMID: 30310315⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
No pathogenic variants reported on ClinVar for this gene.
No tissue expression data available for this gene.