KSR1 (kinase suppressor of Ras 1) functions primarily as a molecular scaffold protein that facilitates signal transduction in the Ras-Raf-MEK-ERK pathway 1. As a scaffold, KSR1 assembles different cellular components to promote phosphorylation of Raf family members and activation of downstream MAP kinases 1. KSR1 acts as an allosteric activator of BRAF by binding to MEK1/MEK2, forming dimers with BRAF that enhance BRAF-mediated phosphorylation of MEK proteins 2. The protein exhibits dual functionality, possessing both pseudokinase and active kinase properties, with its kinase activity becoming activated under specific pathological conditions such as inflammatory bowel disease 34. KSR1 is significantly overexpressed in various cancers, including colon tumors and small cell lung cancer, where it promotes tumor cell survival by regulating Myc and PGC1β expression 5. In small cell lung cancer, KSR1 mediates tumor initiation and cisplatin resistance, with knockout preventing resistance in >90% of cells 6. KSR1 also contributes to fibrotic diseases by promoting cell proliferation, migration, and fibrosis through the MEK/ERK signaling pathway 7. These findings establish KSR1 as a critical regulator in both normal cellular signaling and disease pathogenesis.