LAMC1 (laminin subunit gamma 1) encodes a critical component of laminin heterotrimers that form structural elements of basement membranes in the extracellular matrix 1. As part of various laminin complexes including laminin-111, -311, -321, -411, -421, and -511, LAMC1 facilitates cell adhesion, migration, and tissue organization during development 1. The protein functions through high-affinity receptor binding to mediate cellular attachment and substrate adhesion-dependent cell spreading. In cancer contexts, LAMC1 demonstrates significant pathological relevance across multiple malignancies. In gastric cancer, tumor-secreted LAMC1 promotes peritoneal metastasis by inducing preadipocyte differentiation and creating pre-metastatic niches through a palmitic acid/p-STAT3/miR-193a-3p regulatory pathway 2. LAMC1 expression is associated with poor disease-free survival in hepatocellular carcinoma patients and represents a potential therapeutic target 3. In colorectal cancer, LAMC1 shows particularly strong association with rectal cancer risk and has been identified as a druggable target through genomic analyses 45. Additionally, LAMC1 contributes to endothelial dysfunction in hyperglycemic conditions, regulating platelet-endothelium interactions that may contribute to thrombotic complications in diabetes 6. The protein also serves as a biomarker for therapeutic response prediction in melanoma anti-PD-1 therapy 7.