LAMC2 (laminin subunit gamma 2) encodes a critical component of laminin-332 and laminin-522 trimers that functions as an extracellular matrix structural constituent with diverse roles in cellular processes and disease. The protein promotes cell attachment, migration, and tissue organization during development, while also serving as a key regulator of cellular stress responses 1. In cancer contexts, LAMC2 exhibits dual functionality: it acts as a tumor-initiating cell marker associated with enhanced metastatic potential and poor prognosis across multiple cancer types 23. Mechanistically, LAMC2 mitigates endoplasmic reticulum stress by forming protein complexes with MYH9 and MYH10, promoting ER-mitochondria interactions and cellular adaptation to stressful conditions 4. The protein shows dynamic expression patterns during cancer progression, with distinct senescent tumor cell populations expressing different LAMC2 levels correlating with invasive behavior 5. LAMC2 is associated with junctional epidermolysis bullosa when mutated, and genome-wide association studies identify it as a potential therapeutic target for stroke 6. In therapeutic contexts, LAMC2 expression changes with tyrosine kinase inhibitor treatment, contributing to drug resistance mechanisms in non-small cell lung cancer 7.