LAMC3 encodes laminin subunit gamma 3, a component of basement membrane extracellular matrix molecules present in skin, heart, lung, brain, and retina 1. As a laminin subunit, LAMC3 mediates cell attachment, migration, and tissue organization during development through interactions with extracellular matrix components and cell adhesion receptors. LAMC3 is involved in cortical development, with mutations causing complex bilateral occipital cortical malformations including polymicrogyria, pachygyria, and periventricular nodular heterotopia 234. De novo LAMC3 mutations have been identified in sporadic autism spectrum disorder cases 5. Beyond neurodevelopment, LAMC3 expression is significantly decreased in ovarian cancer tissues, particularly in chemotherapy-resistant and advanced-stage tumors 6. Low LAMC3 expression correlates with poor disease-free and overall survival in ovarian cancer, and LAMC3 interference reduces drug resistance in carboplatin-resistant cells by affecting cell cycle, autophagy, ferroptosis, and lysosome pathways 76. LAMC3 has also been identified as a novel fusion partner in acute myeloid leukemia with NUP98 rearrangements 8. These findings establish LAMC3 as a multifunctional protein critical for cortical development and a potential biomarker for cancer prognosis and therapeutic targeting.