LANCL2 (LanC-like glutathione S-transferase 2) is a peripheral membrane protein that functions as the mammalian abscisic acid (ABA) receptor 1. Primary function: LANCL2 is necessary for ABA binding on the cell membrane and activation of ABA signaling in granulocytes and other immune cells 2. Mechanism: N-terminal glycine myristoylation targets LANCL2 to the plasma membrane and cytoplasmic vesicles, where it interacts with Gi-protein α subunits to initiate G-protein-coupled receptor signaling via cAMP 13. Demyristoylation triggers nuclear translocation 1. LANCL2 also binds phosphatidylinositol phosphates and regulates the cortical actin cytoskeleton 3. Disease relevance: LANCL2 activation enhances regulatory T cell responses and shows therapeutic efficacy in autoimmune diseases including inflammatory bowel disease, lupus, and rheumatoid arthritis 4. Conversely, LANCL2 is upregulated in gastric cancer and glioblastoma, where its nuclear translocation promotes tumor progression through STAT3/Cortactin signaling 56. Additionally, LANCL2 maintains testicular redox homeostasis and acrosomal maturation in spermatogenesis 7. Clinical significance: LANCL2 represents both a therapeutic target for autoimmune diseases and a potential prognostic biomarker for malignancies.