LCE1C (late cornified envelope 1C) is a precursor protein essential for cornified envelope formation in the stratum corneum, functioning at a relatively late stage of epithelial development 1. The gene serves as a skin-specific marker with characteristic expression patterns, making it valuable for tissue identification applications 23. LCE1C expression is transcriptionally regulated by TAp63 phosphorylated at T46/T281 1. Functionally, LCE1C protein interacts with protein arginine methyltransferase 5 (PRMT5) and facilitates its translocation from nucleus to cytoplasm, potentially preventing PRMT5's nuclear function 1. The protein also associates with importin-α, suggesting involvement in nuclear transport processes 1. LCE1C demonstrates reliable expression patterns in calcium-induced keratinocyte differentiation models, making it one of only four markers that faithfully reproduce in vivo expression patterns in vitro 4. The gene shows genetic associations with disease susceptibility, including psoriasis vulgaris in Mongolian populations 5 and appears among cross-talk genes between periodontitis and hypothyroidism 6. Additionally, LCE1C responds to mechanical stretch stimulation in dermal fibroblasts, suggesting roles in mechanotransduction during tissue development 7.