LCE1F (late cornified envelope 1F) is a structural protein precursor that functions as a component of the cornified envelope in the stratum corneum 1. As a member of the Late Cornified Envelope Group I (LCE1) gene cluster, LCE1F exhibits protein binding capabilities and can form identical protein interactions [GO annotations]. LCE1F represents a novel downstream target of the tumor suppressor p53, with expression significantly induced by DNA damage (adriamycin or UV irradiation) in a p53-dependent manner 1. Mechanistically, LCE1F interacts with protein arginine methyltransferase 5 (PRMT5) and modulates its activity; LCE1F overexpression decreases symmetric dimethylation of histone H3 arginine 8, suggesting a role in epigenetic regulation 1. In disease contexts, LCE1F was identified among the top 10 cross-talk genes between periodontitis and hypothyroidism, playing important roles in developmental processes and cell differentiation 2. Additionally, LCE1F expression increases dose-dependently with UVC radiation exposure and is coexpressed with genes involved in p53 signaling-mediated DNA damage response and apoptosis 3. These findings suggest LCE1F contributes to tumor suppression and cellular stress responses through PRMT5 modulation and p53-dependent pathways.