Based on limited published evidence, LCE2A encodes a precursor protein of the cornified envelope in the stratum corneum, the outermost layer of epidermis. The protein exhibits protein binding capability. In a transcriptomic analysis study, LCE2A was identified as one of the top 10 genes showing genetic cross-talk between periodontitis and hypothyroidism, suggesting potential involvement in immune and developmental processes 1. However, detailed functional characterization remains limited.