LGI2 (leucine rich repeat LGI family member 2) is a secreted protein that plays a critical role in neural development and synaptic function. The protein belongs to the LGI family of beta-propeller domain proteins with EPTP/EAR epilepsy-associated repeats and is secreted to the extracellular medium in glycosylated form, similar to its family member LGI1 1. LGI2 is required for the development of soma-targeting inhibitory GABAergic synapses made by parvalbumin-positive basket cells, functioning in inhibitory synapse assembly within the extracellular region. The protein shares structural and functional similarities with LGI1, including similar secretion mechanisms and molecular pathogenesis pathways 1. Mutations in LGI2 are associated with epilepsy disorders, particularly in canine models where an LGI2 mutation has been identified in Lagotto Romagnolo dogs with focal, juvenile remitting epilepsy 2. LGI2 has been proposed as a prime candidate gene for partial epilepsy with pericentral spikes (PEPS) in humans, based on its chr4 location at 4p15 and protein sequence analysis 3. The LGI gene family evolved early in vertebrate lineage and experiences high levels of purifying selection, indicating essential roles in neural development and function 4.