GABRE encodes the epsilon subunit of GABA type A receptors (GABAARs), heteropentameric ligand-gated chloride channels that mediate inhibitory neurotransmission in the brain 1. The epsilon subunit assembles with four other subunits around a central pore to form functional GABAARs, which selectively conduct chloride ions across cell membranes upon activation by GABA 1. Uniquely, GABRE-containing GABAARs permit both spontaneous chloride channel activity and GABA-gated openings, distinguishing them from other GABAR subtypes 1. The gene is transcribed at variable levels across tissues, with highest expression in adult heart and placenta, and undergoes complex alternative splicing that yields distinct protein variants in different tissues 1. GABRE is located on chromosome X, clustered with other GABAR subunit genes in a genomic region associated with neurologic diseases 1. Functionally, GABRE may regulate cardiac function 1. Clinically, GABRE polymorphisms show associations with neuropsychiatric conditions: elevated GABRE expression contributes to schizophrenia-like behaviors in animal models, with downregulation via magnetic stimulation reversing these symptoms 2. Additionally, GABRE has emerged as a biomarker candidate in liver fibrosis, with altered expression correlating with immune infiltration patterns 3. Genetic variants in GABRE show modest associations with migraine onset age in females 4, though not with essential tremor risk 5.