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1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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LGTN
ligatin
NCBI Gene: 100529141
6PubMed Papers
0Diseases
0Drugs
0Pathogenic Variants
✦AI Summary

Based on limited published evidence, LGTN (ligatin) function remains largely uncharacterized. UniProt and GO annotations provide no established molecular or biological functions for this gene. The only published finding indicates LGTN is down-regulated in cutaneous squamous cell carcinoma (SCC) and actinic keratosis (AK) compared to normal skin 1, suggesting potential involvement in skin carcinogenesis, though the specific mechanism is unknown. Further investigation is required to determine LGTN's cellular role and functional significance.

Sources cited
1
LGTN is down-regulated in cutaneous squamous cell carcinoma and actinic keratosis compared to normal skin
PMID: 16865251
⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
EIF1Protein interaction100%EIF5BProtein interaction99%RPS3Protein interaction99%ABCE1Protein interaction99%FAUProtein interaction99%RPS6Protein interaction98%
Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network
Click a node to explore
LGTNEIF1EIF5BRPS3ABCE1FAURPS6
PROTEIN STRUCTURE
?
No structure data available
Structures require a reviewed Swiss-Prot entry.
RankingsWhere LGTN stands among ~20K protein-coding genes
  • #18,110of 20,598
    Most Researched6
Genes detectedLGTN
Sources retrieved1 papers
Response time—
📄 Sources
1
1
Identification of dysregulated genes in cutaneous squamous cell carcinoma.
PMID: 16865251
Oncol Rep · 2006
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