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10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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LHB
luteinizing hormone subunit beta
Chromosome 19 · 19q13.33
NCBI Gene: 3972Ensembl: ENSG00000104826.15HGNC: HGNC:6584UniProt: A0A0F7RQE6
85PubMed Papers
21Diseases
0Drugs
6Pathogenic Variants
CLINICAL
OMIM Disease Gene
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingluteinizing hormone signaling pathwayGO:0005615ovarian follicle developmenthypogonadotropic hypogonadism 23 with or without anosmiaLeydig cell hypoplasia due to LHB deficiencyhepatocellular carcinomaKallmann syndrome
✦AI Summary

Insufficient information available. The provided PubMed abstracts do not contain relevant data about LHB (luteinizing hormone subunit beta) gene function. The abstracts exclusively discuss the lateral habenula (LHb), a brain structure involved in emotional regulation and depression pathophysiology 12345, and the long head of biceps (LHB) tendon, an anatomical structure of the shoulder 678. These topics are unrelated to the LHB gene on chromosome 19 that encodes the luteinizing hormone beta subunit. According to provided sources, LHB normally promotes spermatogenesis and ovulation by stimulating steroid synthesis in gonads. The gene is associated with hypogonadotropic hypogonadism 23, a condition affecting reproductive hormone signaling. However, no PubMed abstracts in this dataset specifically address LHB gene function, expression regulation, molecular mechanisms, or disease pathology. To properly summarize LHB gene function with appropriate citations, abstracts directly investigating luteinizing hormone biology, gonadotropin signaling pathways, or LHB genetic mutations would be required.

Sources cited
1
Discusses lateral habenula (LHb) brain structure, not LHB gene; irrelevant to luteinizing hormone beta subunit
PMID: 40205038
2
Discusses lateral habenula (LHb) brain circuits and depression, not LHB gene
PMID: 32269316
3
Discusses long head of biceps (LHB) tendon anatomy and shoulder pathology, not LHB gene
PMID: 36978047
4
Discusses lateral habenula (LHb) neural circuits and social fear, not LHB gene
PMID: 38963812
5
Discusses lateral habenula (LHb) molecular mechanisms in depression, not LHB gene
PMID: 23990563
6
Discusses lateral habenula (LHb) in depression pathophysiology, not LHB gene
PMID: 29175713
7
Discusses long head of biceps (LHB) tendon surgical management, not LHB gene
PMID: 18703977
8
Discusses long head of biceps (LHB) tendon tenodesis procedure, not LHB gene
PMID: 26866316
Disease Associationsⓘ21
hypogonadotropic hypogonadism 23 with or without anosmiaOpen Targets
0.68Moderate
Leydig cell hypoplasia due to LHB deficiencyOpen Targets
0.64Moderate
hepatocellular carcinomaOpen Targets
0.09Suggestive
Kallmann syndromeOpen Targets
0.08Suggestive
azoospermiaOpen Targets
0.07Suggestive
hypogonadotropic hypogonadismOpen Targets
0.07Suggestive
46,XX gonadal dysgenesisOpen Targets
0.07Suggestive
primary ovarian insufficiencyOpen Targets
0.07Suggestive
46,XX testicular disorder of sex developmentOpen Targets
0.06Suggestive
Isolated follicle stimulating hormone deficiencyOpen Targets
0.06Suggestive
Testicular regression syndromeOpen Targets
0.06Suggestive
partial androgen insensitivity syndromeOpen Targets
0.06Suggestive
46,XY gonadal dysgenesis - motor and sensory neuropathyOpen Targets
0.06Suggestive
46,XY gonadal dysgenesis-motor and sensory neuropathy syndromeOpen Targets
0.06Suggestive
neoplasmOpen Targets
0.06Suggestive
46,XY complete gonadal dysgenesisOpen Targets
0.06Suggestive
46,XY disorder of sex development due to 5-alpha-reductase 2 deficiencyOpen Targets
0.06Suggestive
46,XX ovotesticular disorder of sex developmentOpen Targets
0.06Suggestive
Mayer-Rokitansky-Küster-Hauser syndromeOpen Targets
0.06Suggestive
partial chromosome Y deletionOpen Targets
0.06Suggestive
Hypogonadotropic hypogonadism 23 with or without anosmiaUniProt
Pathogenic Variants6
NM_000894.3(LHB):c.28_39del (p.Leu10_Leu13del)Pathogenic
Isolated lutropin deficiency
☆☆☆☆2012→ Residue 10
NM_000894.3(LHB):c.183+1G>TPathogenic
Isolated lutropin deficiency
☆☆☆☆2012
NM_000894.3(LHB):c.88_96del (p.His30_Ile32del)Pathogenic
Isolated lutropin deficiency
☆☆☆☆2009→ Residue 30
NM_000894.3(LHB):c.167G>A (p.Gly56Asp)Pathogenic
Isolated lutropin deficiency
☆☆☆☆2009→ Residue 56
NM_000894.3(LHB):c.183+1G>CPathogenic
Isolated lutropin deficiency
☆☆☆☆2007
NM_000894.3(LHB):c.221A>G (p.Gln74Arg)Pathogenic
Isolated lutropin deficiency
☆☆☆☆1992→ Residue 74
View on ClinVar ↗
Related Genes
CHST8Protein interaction76%LHCGRProtein interaction69%CGAProtein interaction57%TRHShared pathway40%TFAP2CShared pathway33%CGB3Shared pathway33%
Tissue Expression6 tissues
Lung
100%
Liver
75%
Ovary
44%
Brain
0%
Heart
0%
Bone Marrow
0%
Gene Interaction Network
Click a node to explore
LHBCHST8LHCGRCGATRHTFAP2CCGB3
PROTEIN STRUCTURE
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AlphaFoldAI-predicted · UniProt P01229
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
1.60LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.98 [0.62–1.60]
RankingsWhere LHB stands among ~20K protein-coding genes
  • #5,616of 20,598
    Most Researched85
  • #3,354of 5,498
    Most Pathogenic Variants6
  • #15,681of 17,882
    Most Constrained (LOEUF)1.60
Genes detectedLHB
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Stress dynamically modulates neuronal autophagy to gate depression onset.
PMID: 40205038
Nature · 2025
1.00
2
Circuits and functions of the lateral habenula in health and in disease.
PMID: 32269316
Nat Rev Neurosci · 2020
0.90
3
The long head of biceps at the shoulder: a scoping review.
PMID: 36978047
BMC Musculoskelet Disord · 2023
0.80
4
A prefrontal-habenular circuitry regulates social fear behaviour.
PMID: 38963812
Brain · 2024
0.70
5
βCaMKII in lateral habenula mediates core symptoms of depression.
PMID: 23990563
Science · 2013
0.60