LHCGR encodes the luteinizing hormone/choriogonadotropin receptor, a G-protein coupled receptor that binds both luteinizing hormone (LH) and human chorionic gonadotropin (hCG) 1. The receptor mediates its activity through G proteins that activate adenylyl cyclase signaling pathways 2. LHCGR activation follows a distinctive 'push-and-pull' mechanism where hormone binding pushes the extracellular domain upward while a conserved 10-residue fragment (P10) from the hinge loop acts as a tethered agonist to induce transmembrane domain conformational changes 1. The receptor plays essential roles in reproductive physiology, including ovarian follicle development, steroidogenesis, and corpus luteum maintenance 34. LHCGR expression is regulated by transcription factors including SP1 and shows positive feedback regulation by hCG 4. Inactivating mutations cause a spectrum of disorders from Leydig cell hypoplasia and ambiguous genitalia in males to primary amenorrhea and infertility in females 2. The receptor has been implicated in polycystic ovary syndrome pathogenesis 5 and primary ovarian insufficiency 6. Beyond reproductive tissues, aberrant LHCGR expression occurs in various endocrine tumors including adrenal adenomas and pheochromocytomas 7.