LINGO3 (leucine rich repeat and Ig domain containing 3) is a plasma membrane-localized signaling receptor that functions in tissue regeneration and neurological processes. LINGO3 is broadly expressed on enterocytes and in the intestinal crypt niche, where it plays a role in mucosal wound healing and intestinal stem cell maintenance 1. The protein promotes recovery from colitis through interaction with TFF2, regulating signaling pathways critical for cell proliferation and wound repair 1. In the central nervous system, LINGO3 is differentially expressed and forms heteromeric complexes with other LINGO family members, suggesting regulatory complexity in nervous system function 2. LINGO3 has emerged as clinically relevant in psychiatric and environmental health contexts. DNA methylation changes in LINGO3 are associated with stress-related depression 3 and with perinatal asphyxia in patients with schizophrenia and bipolar disorder, where divergent epigenetic responses may contribute to psychiatric disease risk 4. Additionally, LINGO3 methylation associates with chr19 arsenic exposure in low-to-moderate exposure populations 5, and LINGO3 expression is upregulated in inflamed dental pulp tissues of COVID-19-affected individuals 6. These findings suggest LINGO3 involvement in tissue repair, neurodevelopment, and stress-responsive processes with potential biomarker applications.