LINGO1 (leucine rich repeat and Ig domain containing 1) is a membrane protein that functions as a key negative regulator of central nervous system development and regeneration. The protein serves as a functional component of the Nogo receptor signaling complex, contributing to RhoA activation and inhibition of axonal regeneration by myelin-associated factors 12. LINGO1 acts as an important negative regulator of oligodendrocyte differentiation and axonal myelination, playing a crucial role in the initial myelination process in the CNS 34. The gene shows significant disease associations, particularly with movement disorders. Meta-analysis studies demonstrate that LINGO1 polymorphisms (rs11856808 and rs9652490) are associated with increased risk for essential tremor, especially familial forms 5. Additionally, LINGO1 variants show protective effects against Parkinson's disease in Italian populations 6. Recent omics analyses reveal that LINGO1 is highly enriched in human Alzheimer's disease microglia, suggesting potential involvement in neurodegeneration 7. In cancer contexts, LINGO1 appears to function as a positive prognostic marker in primary glioblastoma 8. These findings establish LINGO1 as a critical regulator of neuronal development, myelination, and neurological disease susceptibility.