LMNA encodes lamin A/C proteins, which are primary components of the nuclear lamina - a proteinaceous meshwork underlying the inner nuclear membrane that is essential for proper nuclear architecture 1. The protein serves crucial roles in maintaining cellular structural stability, regulating gene expression, mechanosensing, and cellular motility 2. Lamin A/C is involved in chr1 organization, gene transcription regulation, and cellular resistance to mechanical stress 34. The protein also interacts with sirtuin 1 (SIRT1) to regulate mitochondrial function and oxidative stress 5. Mutations in LMNA cause a diverse spectrum of diseases collectively termed laminopathies, including cardiomyopathies, muscular dystrophies, lipodystrophies, and premature aging syndromes 12. LMNA-related cardiomyopathy exhibits high penetrance with early-onset phenotypes leading to heart failure and lethal arrhythmias 6. Notably, Hutchinson-Gilford Progeria Syndrome results from aberrant LMNA splicing that produces progerin, a truncated mutant protein causing severe premature aging 17. Clinical significance is substantial as these conditions are resistant to conventional therapies, creating major unmet medical needs, though gene therapy approaches show promise 6.