LPAR6 (lysophosphatidic acid receptor 6) is a G-protein-coupled receptor that binds lysophosphatidic acid (LPA) and plays crucial roles in hair development and cancer biology 1. The receptor exhibits a distinct ligand binding mode compared to other LPA receptors, with LPA forming extensive polar interactions with transmembrane helices and extracellular loops 1. LPAR6 couples to G13 and Gq proteins to mediate downstream signaling pathways 1. Loss-of-function mutations in LPAR6 cause autosomal recessive woolly hair and hypotrichosis, characterized by sparse, tightly curled hair that breaks easily 23. These mutations include point mutations and complete gene deletions, with some founder mutations identified in Pakistani populations 23. In cancer contexts, LPAR6 shows tissue-specific effects: it supports tumorigenicity in hepatocellular carcinoma through STAT3-dependent upregulation of Pim-3 4, while higher LPAR6 expression correlates with better survival in lung adenocarcinoma, possibly through enhanced immune cell infiltration 5. LPAR6 also contributes to bladder carcinogenesis when downregulated, disrupting urothelial differentiation programs 6. These findings establish LPAR6 as both a critical regulator of hair follicle biology and a context-dependent cancer biomarker.