LIPH encodes lipase H, a membrane-associated phosphatidic acid-selective phospholipase A1α that specifically hydrolyzes phosphatidic acid (PA) to produce lysophosphatidic acid (LPA) and fatty acids 1. This enzyme is localized to the outer leaflet of the plasma membrane and does not hydrolyze other phospholipids. LIPH functions through the LPA/LPAR signaling axis, where the produced LPA acts as a bioactive lipid mediator 1. In hair follicles, LIPH is expressed in the outer root sheath and plays a crucial role in hair growth and development, with reduced LIPH-LPA-LPAR6 signaling leading to decreased EGFR transactivation and underdeveloped hair phenotypes 2. Loss-of-function mutations in LIPH cause autosomal recessive woolly hair/hypotrichosis (ARWH2), characterized by sparse, tightly curled hair 32. The disease shows population-specific founder mutations, including deletion of exon 4 in Russian populations and specific point mutations (c.736T>A, c.742C>A) prevalent in Japanese families 2. Beyond hair disorders, LIPH is upregulated in breast cancer and pancreatic ductal adenocarcinoma, where it promotes glycolysis, metastasis, and cancer stem cell properties through LPA/LPAR axis activation 41. Topical minoxidil shows promise as a treatment for LIPH-related hair disorders 2.