ABHD15 (abhydrolase domain containing 15) is a lipid metabolic enzyme primarily expressed in adipose tissue that plays critical roles in glucose homeostasis, adipocyte development, and cellular stress responses. In white adipose tissue, ABHD15 is essential for insulin's anti-lipolytic action by stabilizing phosphodiesterase 3B (PDE3B), thereby suppressing PKA activity and hormone-sensitive lipase phosphorylation to prevent fatty acid mobilization 1. ABHD15 functions as a direct PPARγ target gene and is upregulated during adipogenesis, where it protects adipocytes from apoptosis through BCL-2 pathway activation 2. Notably, ABHD15 expression is decreased in obesity and diabetes, contributing to impaired insulin signaling and elevated circulating fatty acids 1. Beyond adipose tissue, ABHD15 promotes cardiomyocyte viability under hypoxic stress by enhancing glucose uptake, GLUT4 translocation, and glycolytic flux while inhibiting apoptosis via IR/PI3K/AKT and IR/Raf/ERK signaling pathways 3. These findings identify ABHD15 as a potential therapeutic target for metabolic disorders including insulin resistance and myocardial infarction.