PLA1A (phospholipase A1 member A) is a phosphatidylserine-specific enzyme that hydrolyzes sn-1 fatty acids from phosphatidylserine (PS) to produce lysophosphatidylserine (lysoPS) 1. The enzyme belongs to the pancreatic lipase family and is expressed in various human tissues including liver, lung, prostate, and immune cells 1. PLA1A functions through the autotaxin-lysophosphatidic acid receptor axis, where generated lysoPS is converted to lysophosphatidic acid (LPA) by autotaxin, subsequently activating downstream signaling pathways 2. The enzyme plays critical roles in multiple disease processes. In viral infection, PLA1A serves as an essential host factor for hepatitis C virus assembly by facilitating NS2-E2 and NS2-NS5A protein complex formation and bridging viral replication and assembly machinery 34. Clinically, elevated PLA1A levels are associated with autoimmune disorders including rheumatoid arthritis, systemic lupus erythematosus, and early-diagnosed arthritis 2. High expression correlates with metastatic melanomas and contributes to cardiometabolic disorders through cholesterol transportation 1. PLA1A also regulates immune cell functions including T cells, dendritic cells, macrophages, and mast cells through lysoPS signaling via receptors GPR34, GPR174, and P2Y10 1. In kidney transplant rejection, PLA1A expression strongly correlates with active molecular rejection processes 5.