MBOAT1 (membrane bound O-acyltransferase 1) is an acyltransferase that catalyzes acyl-CoA transfer to lysophospholipids, producing phospholipids through the Lands cycle phospholipid remodeling pathway 1. It preferentially acts on lysophosphatidylserine and lysophosphatidylethanolamine, with oleoyl-CoA as the preferred acyl donor 1. Beyond canonical lipid remodeling, MBOAT1 functions as a ferroptosis suppressor by remodeling cellular phospholipid profiles independently of GPX4 or FSP1 2. This ferroptosis-protective function is transcriptionally regulated by estrogen and androgen receptors, linking MBOAT1 to hormone-dependent diseases 23. MBOAT1 dysregulation associates with multiple pathologies: mutations cause male infertility through defective spermatogenesis 4, elevated expression promotes glioma progression via ferroptosis resistance and immunosuppression 5, and altered expression contributes to endometriosis progression 3 and polycystic ovary syndrome risk 6. Additionally, MBOAT1 regulates specific lipid species affecting meat flavor in ruminants 7. The MBOAT1/2 ferroptosis pathway represents an emerging therapeutic target across kidney diseases, cancer, and reproductive disorders 89.