MBOAT2 is an acyltransferase that catalyzes the reacylation of lysophospholipids in the Lands cycle of phospholipid remodeling 1. It preferentially acylates lysophosphatidylethanolamine and lysophosphatidic acid, with oleoyl-CoA as its preferred acyl donor 1. Beyond canonical lipid remodeling, MBOAT2 functions as a ferroptosis suppressor by remodeling cellular phospholipid profiles in a manner independent of GPX4 or FSP1 2. Its ferroptosis-regulatory function is transcriptionally controlled by sex hormone receptors—estrogen receptor and androgen receptor—offering therapeutic potential in hormone-responsive cancers 2. MBOAT2 expression correlates with improved survival across multiple cancer types and associates with immune checkpoint regulation, suggesting roles in cancer immunity 3. In prostate cancer, MBOAT2 is identified as an AR-regulated mediator of ferroptosis resistance, making it a target for precision oncology approaches combining ferroptosis induction with androgen-targeted therapy 4. CircRNA derived from MBOAT2 locus promotes intrahepatic cholangiocarcinoma progression by stabilizing PTBP1 and regulating lipid metabolism reprogramming 5. Additionally, circRNA MBOAT2 regulates angiogenesis via the miR-495/NOTCH1 axis in coronary disease and pancreatic cancer contexts 67, and serves as a biomarker for cardiopulmonary adaptation in athletes 8.