LRPPRC (leucine-rich pentatricopeptide repeat containing) is a multifunctional RNA-binding protein with dual roles in nuclear and mitochondrial gene expression 1. In the nucleus, LRPPRC promotes mRNA export by binding simultaneously to EIF4E and the 4ESE motif, facilitating assembly of the nuclear export complex and trafficking through XPO1/CRM1 to the cytoplasm 1. In mitochondria, LRPPRC functions as a holdase that maintains mt-mRNA secondary structures essential for efficient translation 2. It regulates mitochondrial gene expression by stabilizing mRNAs encoding cytochrome c oxidase subunits and cooperates with PPARGC1A in metabolic regulation 1. LRPPRC suppresses basal autophagy and mitophagy by sustaining BCL2 levels, maintaining mitochondrial potential 1. Additionally, LRPPRC functions as an m6A reader that stabilizes LDHA mRNA to promote glycolysis in cancer cells 3. Disease associations include mitochondrial complex IV deficiency and Leigh syndrome French-Canadian 1. LRPPRC dysregulation contributes to cancer progression, viral infections, and neurodegenerative processes 1. Notably, LRPPRC promotes CDK4/6 inhibitor resistance in lung cancer through a feedback loop with CDK6 4, while viral NS1 proteins antagonize LRPPRC's autophagy inhibition to enhance viral replication 5.