MAPRE3 is a plus-end tracking protein (+TIP) that binds to microtubule plus-ends and promotes microtubule growth and dynamics 12. It stabilizes microtubules at centrosomes for spindle function and regulates minus-end microtubule organization by recruiting CAMSAP2 to the Golgi apparatus, enabling polarized cell movement 2. MAPRE3 is co-expressed with ADNP and SIRT1 in neurons, where it amplifies microtubule dynamics critical for synapse formation and axonal transport 3. Clinically, MAPRE3 has emerged as a tumor suppressor: it is downregulated in ovarian cancer tissues and its overexpression inhibits cancer cell proliferation and tumor growth in vivo 4. MAPRE3 is epigenetically repressed by EZH2 through H3K27me3 enrichment, suggesting the EZH2/MAPRE3 axis as a therapeutic target 4. Beyond oncology, MAPRE3 serves as a protective gene in metabolic disorders, conferring resistance to obesity and metabolic dysfunction through PAK pathway activation 5. MAPRE3 is downregulated in biliary atresia, a pediatric cholestatic disease, where it shows causal association with disease pathogenesis 6. Additionally, MAPRE3 associates with glymphatic system function in the brain, supporting genetic regulation of waste clearance 7.