MARF1 is a cytoplasmic endoribonuclease essential for female meiotic progression and oogenesis 1. Structurally, MARF1 contains a catalytic NYN-like domain with endoribonuclease activity, two RNA recognition motifs (RRMs), and eight LOTUS domains that mediate binding to target mRNAs 12. Mechanistically, MARF1 post-transcriptionally silences gene expression through two complementary pathways: it recruits the DCP1:DCP2 decapping complex to promote 5' decapping and degradation 1, and its LOTUS domains bind CCR4-NOT deadenylase complexes to shorten mRNA poly(A) tails 3. MARF1 predominantly recognizes 3' UTRs of target mRNAs 2. In P-bodies, MARF1 activity is antagonistically regulated by EDC4, which prevents LOTUS domain-mediated target binding 42. During oogenesis, MARF1 represses transposable element expression to maintain germline integrity, functionally analogous to the piRNA system in males 5. In somatic cells, MARF1 regulates genes like IFI44L involved in inflammatory responses 6. MARF1 copy number variations associate with female reproductive traits, indicating clinical relevance to fertility 7.