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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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MAS1
MAS1 proto-oncogene, G protein-coupled receptor
Chromosome 6 · 6q25.3
NCBI Gene: 4142Ensembl: ENSG00000130368.7HGNC: HGNC:6899UniProt: P04201
74PubMed Papers
20Diseases
1Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
OncogeneReceptor
CLINICAL
Clinical Trials
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
cell migrationchemokine-mediated signaling pathwayphospholipase C-activating angiotensin-activated signaling pathwayprotein bindingAbnormality of the skeletal systemhypertensionAbruptio Placentaesarcoma
✦AI Summary

Based on the provided abstracts, information about MAS1 (MAS1 proto-oncogene, G protein-coupled receptor) is limited. The available evidence indicates that MAS1 functions as part of the ACE2/Ang-(1-7)/MAS1 axis within the renin-angiotensin system 1. This axis serves as a counter-regulatory pathway to the classical ACE/Ang II/AT1 axis, where MAS1 acts as a receptor in the vascular system found in arterial and venous endothelial cells and arterial smooth muscle cells 1. The ACE2/Ang-(1-7)/MAS1 axis appears to have vasoprotective functions, inducing vasodilation and attenuating angiotensin II-induced vasoconstriction 1. Additionally, this axis has been documented in ovarian tissues where it may participate in reproductive processes including folliculogenesis, steroidogenesis, oocyte maturation, and ovulation 2. However, the provided abstracts lack detailed mechanistic information about MAS1's specific molecular functions, signaling pathways, disease associations, or clinical significance. A comprehensive functional analysis would require additional literature specifically focused on MAS1 characterization.

Sources cited
1
MAS1 is part of the counter-regulatory ACE2/Ang-(1-7)/MAS1 axis in the renin-angiotensin system with vasoprotective functions
PMID: 33511992
2
ACE2/Ang-(1-7)/MAS1 axis is present in ovarian tissues and involved in reproductive processes
PMID: 32604999
⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
Abnormality of the skeletal systemOpen Targets
0.40Moderate
hypertensionOpen Targets
0.34Weak
Abruptio PlacentaeOpen Targets
0.29Weak
sarcomaOpen Targets
0.26Weak
COVID-19Open Targets
0.25Weak
Abnormal lung morphologyOpen Targets
0.21Weak
respiratory failureOpen Targets
0.20Weak
essential hypertensionOpen Targets
0.19Weak
alcohol drinkingOpen Targets
0.19Weak
coronary artery diseaseOpen Targets
0.19Weak
cancerOpen Targets
0.10Weak
focal segmental glomerulosclerosisOpen Targets
0.08Suggestive
nephrotic syndromeOpen Targets
0.08Suggestive
familial idiopathic steroid-resistant nephrotic syndromeOpen Targets
0.08Suggestive
subarachnoid hemorrhageOpen Targets
0.08Suggestive
Ischemic strokeOpen Targets
0.07Suggestive
anemiaOpen Targets
0.07Suggestive
lymphomaOpen Targets
0.07Suggestive
triple-negative breast cancerOpen Targets
0.07Suggestive
Dent diseaseOpen Targets
0.07Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Drug Targets1
TALFIRASTIDEPhase III
Proto-oncogene Mas agonist
sarcoma
Related Genes
AGTProtein interaction97%NPFFProtein interaction96%TMEM18Shared pathway50%SCYL3Shared pathway50%CD248Shared pathway50%AVL9Shared pathway50%
Tissue Expression6 tissues
Brain
100%
Ovary
9%
Lung
7%
Liver
6%
Heart
1%
Bone Marrow
0%
Gene Interaction Network
Click a node to explore
MAS1AGTNPFFTMEM18SCYL3CD248AVL9
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt P04201
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
1.87LoF Tolerant
pLIⓘ
0.32Tolerant
Observed/Expected LoF0.00 [0.00–1.87]
RankingsWhere MAS1 stands among ~20K protein-coding genes
  • #6,410of 20,598
    Most Researched74
  • #16,979of 17,882
    Most Constrained (LOEUF)1.87
Genes detectedMAS1
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Nucleophosmin and cancer.
PMID: 16794633
Nat Rev Cancer · 2006
1.00
2
ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease.
PMID: 33511992
Clin Sci (Lond) · 2021
0.90
3
Involvement of ACE2/Ang-(1-7)/MAS1 Axis in the Regulation of Ovarian Function in Mammals.
PMID: 32604999
Int J Mol Sci · 2020
0.80
4
Medullary thyroid carcinoma.
PMID: 15355445
Clin Endocrinol (Oxf) · 2004
0.70
5
Wnts and the hallmarks of cancer.
PMID: 32385713
Cancer Metastasis Rev · 2020
0.60