Myelin basic protein (MBP) is a major structural component of the central nervous system myelin sheath, essential for both myelin formation and stabilization 1. The classic MBP isoforms constitute one of the most abundant proteins in CNS myelin, while smaller isoforms may facilitate remyelination of demyelinated axons. Non-classic isoforms (Golli-MBPs) function in early brain development and immune signaling, with MBP capable of inducing T-cell proliferation 2. MBP's clinical significance centers on multiple sclerosis (MS) pathogenesis. MBP serves as a potential autoantigen in MS, with T cells and antibodies from MS patients recognizing specific MBP epitopes through cross-reactivity mechanisms 31. Anti-MBP antibodies display remarkable substrate specificity, cleaving MBP at multiple sites with approximately 1000-fold higher affinity for intact MBP than oligopeptide substrates 45. In experimental models, altered MBP peptide ligands suppress experimental allergic encephalomyelitis, a demyelinating disease model of MS 2. Recent evidence suggests MBP elevation correlates with neuroinflammation in neurodegenerative conditions; elevated MBP levels in alpha-synuclein pathology models correlated positively with microglial and astroglial activation markers 6. While MBP's direct role as a primary MS antigen remains unclear, its structural complexity and central involvement in myelin maintenance establish it as a key factor linking nervous system development to neurodegenerative disease.