MCM6 is a core component of the MCM2-7 replicative helicase complex essential for DNA replication initiation and elongation 1. As part of the CDC45-MCM-GINS (CMG) helicase complex, MCM6 helps unwind template DNA during replication and forms one of six ATPase active sites through interaction with neighboring subunits 1. Beyond its canonical replication function, MCM6 serves as a critical oncogenic driver in multiple cancers. In gastric cancer, MCM6 is transcriptionally activated by the YAP-TEAD complex and promotes tumorigenesis through PI3K/Akt/GSK3β signaling; MCM6 inhibition sensitizes cells to chemotherapy by impairing DNA damage response 2. In hepatocellular carcinoma, MCM6 overexpression correlates with poor prognosis and promotes S/G2 cell cycle progression 3. In bladder cancer, MCM6 upregulation drives cisplatin resistance by enhancing DNA damage repair through a positive feedback loop with c-Myc 4. MCM6 also promotes lung adenocarcinoma proliferation and migration synergistically with E6AP 5. Notably, MCM6 harbors disease-associated missense polymorphisms that may impair protein structural integrity 6, and a regulatory SNP in the MCM6 intron associates with lactase persistence 7. These findings establish MCM6 as both a replication regulator and emerging therapeutic target in cancer.